Activating selectively and reliably nociceptive afferents with concentric electrode stimulation: Yes we can! Provided that low stimulus intensities are used!

Activating Selectively and Reliably Nociceptive Afferentswith Concentric Electrode

stimulation: yes we can! Provided that low stimulus intensities are used!

Yes, We Can! (Should We?).

Advocacy: yes we can.

It is an honor and privilege to address you as president of the American Society for Clinical Investigation. For more than 100 years, this organization has represented the best of physician-scientists. Since it is now 2012, there is the possibility that this could be the last ASCI presidential address. But we will assume the Mayans miscalculated and that we should look to the future. With the A...

Yes we can, but do we?

In recent decades, a curious demographic phenomenon has emerged in US science. A high and increasing proportion of PhD students and postdocs, especially in the life sciences, are drawn from beyond the shores of North America. The reasons for this are undoubtedly complex. One factor is the widespread perception in the USA that a career in academic science is marked by low salaries, poor job secu...

Short trains of intra-epidermal electrical stimulation to elicit reliable behavioral and electrophysiological responses to the selective activation of nociceptors in humans.

Currently, the study of nociception in humans relies mainly on thermal stimulation of heat-sensitive nociceptive afferents. To circumvent some limitations of thermal stimulation, it was proposed that intra-epidermal electrical stimulation (IES) could be used as an alternative method to activate nociceptors selectively. The selectivity of IES relies on the fact that it can generate a very focal ...